Venue & Program
Historical Fonseca College building, University of Salamanca.
Wednesday, September 16
16:30
Registration and complimentary coffee and pastries.
17:00
OPENING REMARKS.
17:30
MITOCHONDRIA AND SENESCENCE.
KEYNOTE LECTURE.
Joao Passos. Mayo Clinic, Rochester, Minnesota, USA.
Title TBD.
Joao Passos. Mayo Clinic, Rochester, Minnesota, USA.
Title TBD.
Invited speaker Ana Victoria Lechuga-Vieco. IRB Barcelona.
Mitochondrial heterogeneity and the regulation of cellular stress states.
Mitochondrial heterogeneity and the regulation of cellular stress states.
Selected talks
- The Last Kiss: mitochondrial apoptotic secreted factors drive Apoptosis-Induced Senescence (AIS). Alejandro Failde-Fiestras, CiMUS/USC, Santiago de Compostela.
- MCL-1 links apoptosis resistance to fatty acid metabolism in osimertinib-induced senescent NSCLC cells. Clara Alcón, University of Barcelona.
19:30
Break.
20:30
WELCOME RECEPTION AND DINNER.
Fonseca Chapel. Entrance through the main monumental gate at the Fonseca College.
Fonseca Chapel. Entrance through the main monumental gate at the Fonseca College.
Thursday, September 17
9:30
SESSION 2: SENESCENCE AND CANCER I.
Invited speaker Ana Luisa Correia. Champalimaud Foundation, Lisbon, Portugal.
Tissue-specific immune regulation of metastatic cancer dormancy.
Tissue-specific immune regulation of metastatic cancer dormancy.
Invited speaker Serena Vegna. NKI, Amsterdam, The Netherlands.
Liver macrophage states bridge chronic injury, senescence, and tumor immune evasion.
Liver macrophage states bridge chronic injury, senescence, and tumor immune evasion.
Selected talks
- Aging triggers an immunosuppressive senescent microenvironment promoting lung cancer development and metastasis. Daniel Muñoz-Espín, CRUK Cambridge, UK.
- The immune response pathway as a mediator of paracrine induction of senescent cells in Drosophila. Natalia Azpiazu. CBM Severo Ochoa (CSIC/UAM), Madrid.
- Therapy-induced senescence promotes soluble PD-L2 expression in head and neck squamous cell carcinoma models. María Torres-Martínez, CIC (CSIC/USAL), Salamanca.
11:15
Coffee break.
11:45
SESSION 3: SENESCENCE AND CANCER II.
Invited speaker Verónica Rodilla. Josep Carreras Institute, Barcelona.
Therapy-induced senescence in non-Hodgkin lymphoma: from biomarkers to mechanisms of tumor relapse.
Therapy-induced senescence in non-Hodgkin lymphoma: from biomarkers to mechanisms of tumor relapse.
Selected talks
- Long-term CDK4/6 inhibition rewires the senescence secretome toward a SREBP1-driven protumorigenic program in breast cancer. David Tena-Chaves, CIC (CSIC/USAL), Salamanca.
- Sequential CDK4/6 inhibition following cisplatin promotes a senescence-like response and enhances therapeutic efficacy in HPV-negative HNSCC models. Mónica Álvarez-Fernández, CIC (CSIC/USAL), Salamanca.
- Decoding long-term senescence. Nuria Casa-Rodríguez, IIBM Sols-Morreale (CSIC/UAM), Madrid.
Poster teasers
13:30
Lunch and posters session I (abstracts 1-37).
15:15
SESSION 4: METABOLISM AND SENESCENCE.
Invited speaker María Carmen Gómez Cabrera. University of Valencia, Spain.
Exercise-driven mitochondrial remodeling reverses functional decline with age.
Exercise-driven mitochondrial remodeling reverses functional decline with age.
Selected talks
- TOR-dependent translational control coordinates quiescence entry, telomeric function, and transposable element repression during nutritional stress. Daniel del Cerro Martínez, IBFG (CSIC/USAL), Salamanca.
- A p53-p21-cyclin D2 regulatory axis defines a distinct program of macrophage senescence. Grasiela Torres, UCLA, Los Angeles, USA.
- Senescence disrupts transcriptional and lipid modulation in endothelial cells after mechanical stretch. Edurne Armesto-Longueira, CIB Margarita Salas (CSIC), Madrid.
16:30
Coffee break.
17:00
SESSION 5: DNA DAMAGE AND REPLICATION STRESS.
Invited speaker Panos Galanos. SDU, Odense, Denmark.
Replication stress rewires mitochondrial metabolism to shape senescence evolution.
Replication stress rewires mitochondrial metabolism to shape senescence evolution.
Selected talks
- Dissecting chromatin and DNA damage dynamics in therapy-induced senescence at single-cell resolution. Carlota Davó-Martínez, Hubrecht Institute-KNAW, Utrecht, The Netherlands.
- HCMV engages the STING–p16INK4a axis to drive DNA damage-associated senescence in endothelial cells. Marco de Andrea, University of Turin, Italy.
18:00
End of scientific session.
Cultural visits
- 18:30 Guided visit to Monterrey Palace (in Spanish).
- 19:00 Salamanca free tour (meeting point at Fonseca entrance).
- 19:00 Guided visit to the Cathedral towers.
Friday, September 18
9:30
SESSION 6: SENESCENCE AS A DRIVER OF DISEASE.
Invited speaker Isabel Fariñas. University of Valencia, Spain.
Vascular senescence as a driver of the age-related decline in neurogenesis.
Vascular senescence as a driver of the age-related decline in neurogenesis.
Invited speaker Diana Jurk. Mayo Clinic, Rochester, Minnesota, USA.
The lipid side of senescence: mechanisms and therapeutic potential.
The lipid side of senescence: mechanisms and therapeutic potential.
Selected talks
- Age-dependent HMGB1 loss drives a non-inflammatory senescence program that primes vascular smooth muscle cells for vascular calcification. Angela Raucci, Centro Cardiologico Monzino-IRCCS, Milan, Italy.
- Partial reprogramming mechanisms in mature cortical neurons: implications for ageing and neurodegeneration. Irene Rodríguez-Navarro, UB/IDIBAPS, Barcelona.
- HCMV-induced senescence as a potential driver of congenital malformations. Rocío M. Tolosa, CiMUS, Santiago de Compostela.
11:15
Coffee break.
11:45
SESSION 7: TARGETING SENESCENCE.
Invited speaker Bill Keyes. IBMGC, Strasbourg. France.
Conserved features of cellular senescence across development, aging, and disease.
Conserved features of cellular senescence across development, aging, and disease.
Invited speaker Maria Ikonomopoulou. IMDEA Nutrition, Madrid.
A senotoxin approach: targeting senescent cells to improved chemotherapy outcomes.
A senotoxin approach: targeting senescent cells to improved chemotherapy outcomes.
Selected talks
- Senolytics with a safety catch: a pathogen-activated PROTAC for chronic mycobacterial infection. Federico Russo, University of Milan, Italy.
- Long noncoding RNAs to identify and target therapy induced senescence in ovarian cancer. Niloufar Hosseini Giv, CIMA University of Navarra.
- Investigating pyroptosis resistance and the role of gasdermins in oncogene-induced senescence. Sofía Morán-Zafrilla, IBBTEC, Santander.
- Rewiring of the microtubule network modulates secretion in senescent cells. Lisa Donker, Barts Cancer Institute, London, UK.
Poster teasers
13:45
Lunch and posters session II (abstracts 38-73).
15:30
SESSION 8: REPROGRAMMING AND EPIGENETICS.
Selected talks
- Chemical partial reprogramming as a senomorphic strategy for healthy aging. Lucía Lorenzo-Rodríguez, CiMUS/USC, Santiago de Compostela.
- Reprogramming-derived secretomes attenuate cellular senescence independently of full pluripotency acquisition. Raquel Paredes, CiMUS/USC, Santiago de Compostela.
THE EMBO KEYNOTE LECTURE
Wolf Reik. Cambridge Institute of Science (Altos Labs), Cambridge, United Kingdom.
Epigenetic regulation of development and ageing.
17:00
Closure and prizes.
17:30
SENESCEL assembly.
20:30
Gala dinner.
Restaurante El Monje. Hotel Hospes Palacio de San Esteban.
Arroyo de Santo Domingo, 3.
Restaurante El Monje. Hotel Hospes Palacio de San Esteban.
Arroyo de Santo Domingo, 3.